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Brief Research Description

The research activity focuses on the pathogenesis, prevention, and treatment of Non-Melanoma Skin Cancer (NMSC), which represents the most common neoplasm in the Caucasian population, and of the cutaneous field cancerization (CFC), that refers to a skin region containing mutated cells’ clones, predominantly arising from chronic exposure to ultraviolet radiation (UVR), which exhibits an elevated risk of developing precancerous and neoplastic lesions. In this context, we investigate the expression of keratinocyte differentiation markers, pro- and anti-inflammatory cytokines, and markers of DNA damage in CFC tissue, preneoplastic and neoplastic skin lesions, and the putative role of different vitamins, including alpha-tocopherol and niacinamide to prevent the photoinduced damage in keratinocytes and skin fibroblasts. This research has a translational expansion, which includes the in vivo evaluation of the modifications resulting from different topical and systemic treatments in patients with photodamaged skin or affected by CF and NMSC.

Keywords

Non-melanoma skin cancer, field cancerization, photocarcinogenesis, ultraviolet light, oxidative stress

PubMed