UPO Book

Brief Research Description

Nicoletta Filigheddu's research focuses on the molecular and cellular mechanisms that regulate skeletal muscle physiology in health, aging, and disease, with the aim of identifying therapeutic strategies to preserve muscle mass and function. She works on conditions involving muscle loss, such as cancer cachexia and age-related sarcopenia, studying how metabolic alterations contribute to muscle wasting. She also investigates how different dietary interventions affect muscle homeostasis by targeting mitochondrial function, oxidative stress, and inflammation. Additionally, she studies the role of bioactive molecules in muscle adaptation and regeneration. An important aspect of her research is the crosstalk between skeletal muscle and other organs and tissues, including the liver, adipose tissue, and bone, which communicate through hormones, cytokines, and chemokines. By integrating cellular and systemic perspectives, her research seeks to better understand systemic metabolic dysfunction that leads to muscle loss and to identify potential targets for prevention or treatment of muscle-related disorders.

Keywords

Skeletal muscle, metabolism, mitochondria, oxidative stress, murine models

PubMed

ORCID ID 0000-0002-3848-611X